IMR Press / FBE / Volume 2 / Issue 3 / DOI: 10.2741/E156

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Add-on blockade of (pro)renin receptor in imidapril-treated diabetic SHRsp
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1 Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
2 Department of Endocrinology and AntiAging Medicine, Keio University School of Medicine, Tokyo, Japan
Academic Editor:Fumiaki Suzuki
Front. Biosci. (Elite Ed) 2010, 2(3), 972–979; https://doi.org/10.2741/E156
Published: 1 June 2010
(This article belongs to the Special Issue Handle region peptide and prorenin receptor)
Abstract

To examine the involvement of (pro)renin receptor in the accelerated organ damage in streptozotocin-induced diabetic male SHRsp, the rats fed a high-salt diet were divided into 5 groups: a group treated with the vehicle, a group treated with 15 mg/kg/day of imidapril (ACEi), a group treated with 60 mg/kg/day of imidapril (High ACEi), a group treated with handle region peptide (HRP), and a group treated with both ACEi and HRP (ACEi+HRP). After 8 weeks, the arterial pressure was similar in the vehicle and HRP groups and decreased in the ACEi-treated groups. The renal angiotensin II content decreased similarly in the groups treated with ACEi and/or HRP. Urinary protein excretion also decreased in the ACEi, High ACEi, and HRP groups and significantly further decreased in the ACEi+HRP group. The heart weight of the ACEi+HRP group was significantly lower than that of any other groups, although the cardiac angiotensin II levels decreased similarly in the groups treated with ACEi and/or HRP. Thus, (pro)renin receptor contributes to the accelerated pathogenesis in the heart and kidneys of diabetic SHRsp.

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