IMR Press / FBE / Volume 2 / Issue 3 / DOI: 10.2741/E145

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.


Male-biased genes of Drosophila melanogaster that are conserved in mammalian testis

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1 Reproductive Immunology and Molecular Biology Lab, Department of Obstetrics and Gynecology, West Virginia University, School of Medicine, Health Sciences Center, Morgantown, WV 26506-9186
Front. Biosci. (Elite Ed) 2010, 2(3), 841–848;
Published: 1 June 2010

Male-biased genes have drawn considerable attention due to their relatively rapid rates of interspecies diversification. These genes are often involved in processes related to reproductive behavior, sexual competition, and gametogenesis. Despite this trend toward rapid evolutionary change, many core molecular pathways underlying spermatogenesis are conserved between Drosophila melanogaster and several mammalian species. Using BLAST search in the database, 22 testis-specific mammalian orthologues of 174 known D. melanogaster male-biased proteins were identified. They are related to a variety of molecular processes. Several also showed association with human male-factor infertility. These genes/proteins may find applications in the diagnosis and treatment of male infertility and the development of novel contraceptives.

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