IMR Press / FBE / Volume 14 / Issue 4 / DOI: 10.31083/j.fbe1404024
Open Access Original Research
Cuminaldehyde ameliorates hyperglycemia in diabetic mice
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1 Department of Biochemistry and Biotechnology, Annamalai University, Annamalainagar, 608001 Chidambaram, India
2 Department of Food and nutrition, Pondicherry University, 605002 Pondicherry, India
3 Meenakshi Academy of Higher Education and Research, Central Research Laboratory, 600 078 Chennai, India
4 Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences Department of Biochemistry, Saveetha University, 600 077 Chennai, India
*Correspondence: (Pari Leelavinothan)
Academic Editor: Baohong Zhang
Front. Biosci. (Elite Ed) 2022, 14(4), 24;
Submitted: 31 January 2019 | Revised: 27 September 2021 | Accepted: 27 September 2021 | Published: 21 September 2022
Copyright: © 2022 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license.

Background: Animal-fats are rich in long-chain saturated fatty-acids, well known to induct diabetic distress among ingested insulin-insensitive individuals. In the current-study, bovine-fat was fed to selective mice breeds highly sensitized to heavy dietary lipid load. Methods: The later high fat diet (HFD) group indeed undergone diabetic-onset within weeks with a drastically altered feed-behavior pattern. It consumed more food, gained body mass, elevated homeostatic model assessment value and extensively glycosylated Hb transporters. Results: However, the hypothetical test drug (Cuminaldehyde or CA) with known therapeutic-potential worked-well to balance food efficiency-ratio and Hb- counts closer to control. The fat-soluble phytochemical mono-terpenoid (CA) promoted constitutive mono-hexose (glucose) consuming catabolic-cycles via mono-glycoprotein (insulin) signal-transduction. It resolved diabetogenic-upsurge of gluconeogenic-enzymes, reduced non-sugar (amino/fatty acids) utilization by restricting transamination/dephosphorylation and restored liver-glycogen reserves near to normal-group effectively at 10 mg/kg b.w dose. Conclusions: Hence, the nutraceutical-potential (anti-diabetes/transaminitis ability) of administered exogenous redox-active agent CA can be entertained for evoking therapeutic-heath in diabetic human-community.

High-fat diet
Insulin resistance
Glycosylated hemoglobin
Oral glucose tolerance test
Fig. 1.
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