IMR Press / FBE / Volume 11 / Issue 1 / DOI: 10.2741/E842

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Antiapoptotic role of Agaricus blazei extract in rodent model of Parkinson’s disease
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1 Research Scholar, Bharath Institute of Higher Education and Research, Chennai, Tamil Nadu 600073, India
2 Department of Anatomy,Velammal Medical College, Madurai, Tamil Nadu 625009, India
3 Sree Balaji Medical College, Chennai, Tamil Nadu 600044, India
4 Department of Anatomy, Sree Balaji Medical College, Chennai, Tamil Nadu 600044, India
Send correspondence to: Srinivasagam Rajasankar, Department of Anatomy, Velammal Medical College and Hospital, Madurai, Tamil Nadu 625009, Tel:999454534, Fax:04522970176, E-mail:
Front. Biosci. (Elite Ed) 2019, 11(1), 12–19;
Published: 1 January 2019

Rotenoneis a pesticide that has been shown to induce the pathological symptoms ofParkinson'sdisease(PD) in both cellular and animal models. In this study, we investigated the protective effect of Agaricus blazei extract onrotenone-induceddopaminergic degeneration and apoptosisin mice model. A. blazei extract blocked therotenone-mediated diminution of dopamine transporter (DAT) and vesicular monoamine transporter 2 (VMAT 2) expression and the downregulation of Bcl-2 and the upregulation of Bax, caspases-3, -6, -8 and caspase-9. Present data suggest that A. blazei extract plays a crucial role in regulation of proteins expression such as DAT and VMAT2 and pro-apoptotic and anti-apoptotic in Parkinsonism. In conclusion, the present study shows that A. blazei extract act as potential neuroprotective agent in the management of Parkinsonism.

Figure 1
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