IMR Press / FBE / Volume 1 / Issue 2 / DOI: 10.2741/E49

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Proliferation of cardiomyocytes: a question unresolved
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1 Department of Biological Sciences, Section of Evolutionary and Comparative Biology, University Federico II of Naples, Naples, Italy
2 Department of General Pathology and Oncology, Second University of Naples, Naples, Italy
3 Department of Medicine and Public Health, Section of Anatomy, Second University of Naples, Naples, Italy
Front. Biosci. (Elite Ed) 2009, 1(2), 528–536;
Published: 1 June 2009

In the past, human heart has been considered a post-mitotic organ formed by cells, like adult cardiomyocytes, terminally differentiated and incapable of proliferation. This paradigm has been shaken by recent works indicating that postnatal adult cardiomyocytes are able to re-enter in the cell cycle and proliferate. In this view, the understanding of main candidates regulating cardiomyocyte cell cycle is of vital importance for future clinical approach.

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