Due to late stage diagnosis, the 5 year survival rate is poor in gynecologic cancers, especially ovarian cancer. The early detection is the key for improving survival and preventing the disease. Advances in next-generation sequencing technology and analytical tools have explored the possibility of the noninvasive molecular approaches like circulating biomarkers in early detection of cancers. Circulating biomarkers include circulating tumor DNA (ctDNA), cell free DNA (cfDNA), and exosomes (DNA, RNA, miRNA, proteins, and metabolits) as well as volatile organic compounds. Point mutations, copy number changes, structural alterations, methylation, gene and miRNA expression can be identified in circulating fluid by using next-generation sequencing technology. This special issue aim to capture recent insights and advances about circulating biomarkers, their specificity, sensitivity, challenges and opportunities in early detection of gynecologic cancers, and how this data can be utilized for early detection and prevention of the diseases.
Dr. Musaffe Tuna
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