Human dura mater has been utilized in various reconstructive procedures following radical pelvic surgery at the Division of Gynecologic Oncology, University of Miami School of Medicine. Our preliminary results indicate that this allograft is strong, durable, and acts as a good biological barrier. However, it does not seem to prevent the development of enteropelvic fistulae in patients who undergo total pelvic exenteration following radiotherapy. Dura mater has also been employed in abdominal hernia repairs, repair of wound dehiscenses, and in the coverage of the femoral vessels after groin dissection. Provisional results with these reconstructive techniques appear promising. These results are discussed, and suggestions regarding the use of this allograft are delineated.