IMR Press / EJGO / Volume 7 / Issue 2 / pii/1986020

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Original Research

Early hemostatic disorders in patients with gynecologic tumors

Show Less
1 Department of Obstetrics and Gynecology, Catholic University of the Sacred Heart Rome, Italy
2 Department of Internal Medicine, Catholic University of the Sacred Heart, Rome, Italy
3 Department of Obstetrics and Gynecology, University of Cagliari, Italy
Eur. J. Gynaecol. Oncol. 1986, 7(2), 109–112;
Published: 10 June 1986

One hundred and seventeen female subjects were studied: 23 patients with cervical carcinoma; 25 with endometrial carcinoma; 29 with benign uterine diseases; 14 with ovarian car­cinoma; 26 patients with benign ovarian tumors. These patients, together with 25 healthy female control subjects, underwent several coagulation tests including Beta-Thromboglobulin (Beta-TG) and Platelet Factor 4 (PF4) plasma levels. Among all Beta-TG and PF4 exhibited the most inte­resting results. They were increased in four groups of patients: those with malignant 92.2% (13/14) and benign 50% (13/26) ovarian tumors and those with endometrial 64% (16/25) and cervical carcinoma 69.5% (16/23). Our study showed a high incidence of abnormalities of Beta-TG and PF4, early signs of hemostatic disorders, in gynecological malignancies especially in ovarian carcinoma, These data suggest a possible value of these tests as tumor-markers and in order to detect the patients who develop thrombo-embolic accidents.

Back to top