IMR Press / EJGO / Volume 6 / Issue 3 / pii/1985042

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Original Research

A study of endometrial adenocarcinoma treated with tamoxifen by scanning and transmission electron microscopy

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1 Institute of Oncology - University of Messina, Italy
Eur. J. Gynaecol. Oncol. 1985, 6(3), 176–182;
Published: 10 October 1985

By scanning and transmission electron microscopy the Authors studied four cases of endometrial adenocarcinoma (stage I, Gl) after 15-days treatment with Tamoxifen (20 mg × 2) before surgery. The ultrastructural findings, similar to those observed in untreated adenocarcinomas but quite different from those obtained in MAP-responsive cases - as other Authors reported too - seem to indicate an almost complete absence of secretory or cytotoxic induction at least as far as 15-days treatment is concerned. According to the Authors this study raises many doubts about the usefulness of a firsr-instance therapeutical protocol based on Tamoxifen alone. However they believe that Tamoxifen can be uti­lized combined with a progestational agent in a simultaneous or sequence treatment. 

Endometrial adenocarcinoma
Electron microscopy
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