IMR Press / EJGO / Volume 42 / Issue 6 / DOI: 10.31083/j.ejgo4206188
Open Access Systematic Review
Systematic review and meta-analysis of the use of quilting to prevent seroma formation after mastectomy
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1 Department of Breast Surgery, Luoyang Central Hospital Affiliated to Zhengzhou University, 471009 Luoyang, Henan, China
2 Department of Stomatology, Luoyang Central Hospital Affiliated to Zhengzhou University, 471009 Luoyang, Henan, China
Eur. J. Gynaecol. Oncol. 2021, 42(6), 1303–1309;
Submitted: 20 July 2021 | Revised: 14 August 2021 | Accepted: 16 August 2021 | Published: 15 December 2021
Copyright: © 2021 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license (

Objective: Mastectomy is still a rational option for many women with breast cancer. However, the extensive dissection will lead to a large dead space beneath the flap that hampers the adherence to the tissue bed, which increase the seroma rate. Including flap quilting, several surgical techniques have been used to obliterate the dead space. However, there are conflicting results in the effectiveness at reducing the incidence of seroma. This meta-analysis was conducted to better assess the role of the use of quilting in seroma formation after mastectomy. Data sources, methods of study selection: An extensive literature search was performed in the PubMed, Embase and Cochrane databases. Pooled Odds ratio (OR) with 95% confidence intervals (CI) was analyzed. Tabulation, integration and results: A total of 8 trials involving 984 patients were included. Flap quilting showed seroma rate benefit of 20.1% vs 38.4% (OR 0.24, 95% CI 0.10–0.59, p = 0.002). Conclusion: Quilting significantly decreased the seroma rate in patients with breast cancer undergone mastectomy, and flap quilting is a valuable option for patients.

Breast cancer
Fig. 1.
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