IMR Press / EJGO / Volume 42 / Issue 6 / DOI: 10.31083/j.ejgo4206187
Open Access Review
Current status of diagnosis for synchronous endometrial and ovarian carcinomas by molecular biological approach
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1 Department of Obstetrics and Gynecology, Keio University School of Medicine, 160-8582 Tokyo, Japan
Eur. J. Gynaecol. Oncol. 2021, 42(6), 1300–1302;
Submitted: 11 April 2021 | Revised: 12 July 2021 | Accepted: 23 July 2021 | Published: 15 December 2021
Copyright: © 2021 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license (

The diagnosis of synchronous carcinomas is difficult in all types of cancer. However, in gynecological cancers, synchronous endometrial and ovarian carcinomas are rarely seen and are more difficult to diagnose because the uterus and ovaries are adjacent organs. Although classical pathological criteria have been used for diagnosis, molecular biological methods are increasingly being used to refine diagnostic decisions. Through genomic analyses, such as next-generation sequencing and targeted and exome sequencing, many cases that have been diagnosed and treated as primary synchronous carcinomas have been determined to actually be metastatic carcinomas. It is necessary to establish new diagnostic criteria by incorporating molecular biological methods with conventional pathological diagnosis.

Synchronous endometrial and ovarian carcinoma
Molecular biological approach
Genomic analyses
Next-generation sequencing
Targeted and exome sequencing
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