Positive effects of physical activity on the reduction of the risk of chronic diseases such as cardiovascular diseases, diabetes, hypertension, but primarily to reduce the risk of breast, colorectal and endometrial cancer. The aim of the study was to determine the effect of physical activity on the risk of developing cancer of female reproductive organs. The study involved women with ovarian, cervical, and endometrial cancer (diagnosed on the basis of histopathological evidence) and healthy controls. A total number of 953 women (aged 21 to 84 years) was included. Moderate (600 - 1500 MET) and vigorous (> 1500 MET) physical activity during household chores reduces the risk of ovarian cancer (OC). The odds ratio of developing OC is OR = 0.35; 95% Cl 0.09 - 1.31 and OR = 0.23; 95% Cl 0.07 - 0.80, as compared to women with low physical activity (< 600 MET). The respondents who reported engaging in sports activities between 600 and 1500 MET/day have a lower risk of cervical cancer, OR = 0.52; 95% Cl 0.19 - 1.46. In order to reduce the risk of malignant neoplasia in female reproductive organs, physical effort of 600 - 1500 MET should be undertaken.