IMR Press / EJGO / Volume 41 / Issue 1 / DOI: 10.31083/j.ejgo.2020.01.4806
Open Access Case Report
Poorly differentiated ovarian Sertoli-Leydig cell tumor with heterologous rhabdomyosarcomatous elements associated with elevated serum alpha-fetoprotein level: a case report and review of the literature
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1 Department of Gynecology, Affiliated Hospital of Medical School, Ningbo University, Ningbo, China
2 Diagnostic Pathology Center, Ningbo, China
Eur. J. Gynaecol. Oncol. 2020, 41(1), 138–141;
Published: 15 February 2020

Ovarian Sertoli-Leydig cell tumors (SLCTs) are uncommon sex cord-stromal tumors. Moreover, SLCTs with heterologous mesenchymal elements are extremely rare and usually associated with poor differentiation and prognosis. Herein, the authors describe a case of SLCT involving the right ovary in a 16-year-old girl who presented with acute lower abdominal pain and fever. Serum investigation demonstrated abnormally elevated level of alpha-fetoprotein (AFP), slightly elevation of testosterone, and CA125 concentration. Right salpingo-oopherectomy was performed due to ovarian tumor torsion and then histopathological analysis revealed a poorly differentiated Sertoli-Leydig cell tumor with heterologous rhabdomyosarcomatous elements. A brief review of the literature was conducted to explore the management options for patients with SLCTs and the prognosis.

Sertoli-Leydig cell tumors
Sex cord-stromal tumors
Alpha fetoprotein
Figure 1.
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