IMR Press / EJGO / Volume 40 / Issue 6 / DOI: 10.12892/ejgo4592.2019
Open Access Case Report
Primary cervical choriocarcinoma with germ cell tumor: a case report with literature review
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1 The Medicine Department of Obstetrics and Gynecology, Capital Medical University, Beijing, China
2 Department of Gynecology Tumor, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China
3 Beijing Maternal and Child Health Care Hospital, Beijing, China
Eur. J. Gynaecol. Oncol. 2019, 40(6), 1027–1030;
Published: 10 December 2019

Background: Gestational trophoblastic diseases (GTD) is a series of malignant cancer can be subdivided in pregnancy-associated disease or non-pregnancy choriocarcinoma. The latter among the GTD is extremely rare, particularly primary cervical choriocarcinoma. Case Report: The authors present a case of primary cervical choriocarcinoma with germ cell tumor which is rarely reported. A 46-year-old female visited Beijing Obstetrics and Gynecology hospital because of irregular vaginal bleeding who had undergone radical cervical cancer surgical treatment. After surgery, her symptoms were not visibly changed and the result of pathology suggested cervical cancer. Finally, the authors confirmed its non-gestational origin with ovarian yolk sac tumor by immunohistochemical staining and the level of serum beta-hCG. Fortunately, multiple courses of chemotherapy with BEP regimen were effective for this case. Conclusion: During the course of diagnosis and therapy, immunohistochemical staining and the level of beta-hCG are useful. We could distinguish The tissue origin of this tumor with cervical cancer was distinguished and early diagnosis contributed to the therapy of this disease.

Primary cervical choriocarcinoma
Figure 1.
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