Purpose: Report of one case of ovarian yolk sac tumor (YST) in a postmenopausal patient and review of the literature. Materials and Methods: The case the authors present is of a 77-year-old woman with ovarian YST along with a serous carcinoma and an endometriotic cyst component. They also review and summarize the findings of already reported cases. Results: Sixty cases of ovarian YSTs in postmenopausal patients have been described from 1976 to 2017, including the 23 found in the literature (PubMed and Elsevier) and the one reported in this article. The introduction of bleomycin/ etoposide/ cisplatin (BEP) chemotherapy for malignant germ cell tumors has improved outcomes in premenopausal women, but it does not have a similar impact on postmenopausal patients. Conclusions: The outcome for postmenopausal patients remains poor, even for those presenting with early stage disease or with pure YST. Further research is required to determine the pathogenesis and plan an effective therapy for this age group.