IMR Press / EJGO / Volume 40 / Issue 3 / DOI: 10.12892/ejgo4735.2019
Open Access Original Research
Immunohistochemistry of phosphatase and tensin homolog and metalloproteinase-9 in breast invasive micropapillary carcinoma
Show Less
1 Department of Pathology, the First People's Hospital of Wenling, Wenling , China
2 Department of Pharmacy, Taizhou Enze Hospital, Luqiao, China
3 Department of Pathology, the First Affiliated Hospital of Zhejiang Province Traditional Chinese Medical University, Hangzhou, China
Eur. J. Gynaecol. Oncol. 2019, 40(3), 380–383;
Published: 10 June 2019

Objective: Alteration of phosphatase and tensin homolog (PTEN) and metalloproteinase-9 (MMP-9) expression is involved in carcinogenesis, and both proteins are correlated with malignant cell invasion and metastasis. This study focused on PTEN and MMP-9 expression in the invasive micropapillary carcinoma (IMPC) of the breast and its relationship to clinical pathological features. Materials and Methods: The immunohistochemical S-P method was used to detect the expression levels of PTEN and MMP-9 in 49 cases of IMPC (the proportion of IMPC in breast carcinoma is approximately 5-100%) and 30 cases of normal breast tissue. Results: In IMPC, PTEN, and MM-9 expression levels were negatively and positively related, respectively, to the histopathologic grade and lymph node metastasis (both p < 0.05). The PTEN expression was negatively related to MMP-9 expression (p < 0.05). Conclusion: These results suggest that lack of MMP-9 and PTEN overexpression are early markers of breast carcinogenesis preceding tumor invasion. Apparently, IMPC carries the risk of progression to a malignant phenotype according to these markers. The clinical importance of these finding is discussed.

PTEN phosphohydrolase
Matrix metalloproteinase 9
Invasive micropapillary carcinoma
Figure 1.
Back to top