Objective: Ovarian tumours can be classified as benign, borderline or malignant lesions. The purpose of this study was to assess, inter alia, fibrinogen concentration, and the (C-reactive proteins) and high-sensitivity CRPs (hs-CRPs) levels in the blood serum of patients with ovarian lesions. Study Design: The study involved patients treated laparoscopically and laparotomy in the Gynaecology and Obstetrics Clinical Hospital of the Poznan due to adnexal changes in the form of endometrial cysts and mature teratomas, mucinous cysts, borderline tumors of the ovary, simplex (serosa) cysts or haemorrhagic cysts. Results: The groups differed considerably in fibrinogen (p = 0.022) and d-dimer levels (p = 0.002). Conclusion: Statistically significant differences were found in the fibrinogen and d-dimer profiles among patients with benign and borderline ovarian tumours. However, this requires further investigations in larger patient groups.