IMR Press / EJGO / Volume 39 / Issue 5 / DOI: 10.12892/ejgo4344.2018

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Original Research
The relationship between HPV16 integration and cervical lesions
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1 Tianjin Central Hospital of Gynecology Obstetrics, Tianjin, China
2 Tianjin Medical University, Tianjin, China
†Contributed equally.
Eur. J. Gynaecol. Oncol. 2018, 39(5), 755–759;
Published: 10 October 2018

Aim: Cervical cancer is closely associated with persistent high-risk human papillomavirus (HR-HPV) infection. However, infections will persist in only 20% of the HR-HPV. The integration of the HPV DNA into the host DNA has been proposed as an early event and a risk factor for the progression of cervical lesions. Therefore, the purpose of this study is to evaluate the relationship between the physical status of HPV16 and the severity of cervical lesions based on both cytology and pathology results. Materials and Methods: A total of 150 patients with cervical lesions were enrolled in this study. All patients were HPV-positive, and corresponding pathology results were acquired by biopsy. HPV infection and the expression of HPV16 E2 and E6 forms were analyzed using multiplex-PCR, while the physical status of HPV16 was evaluated using the E2/E6 ratio. Results: The analysis of Spearman rank correlation showed that there were correlations between the integration ratio for HPV16 and the severity of cervical lesions based on both cytology and pathology results (both p <0.05). Conclusion: The integration ratio for HPV16 is closely associated with the severity of cervical lesions based on pathology and cytology and it is also an important risk factor for the persistence and progression of cervical lesions.
Human papillomavirus
Cervical lesions
Cervical cancer
E2 gene
E6 gene
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