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European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.
Original Research
Differential regulation and prognostic significance of endogenous hypoxic markers in endometrial carcinomas
S. Dong Soo1, †, P. Won Young2, †, K. Ki Hyung1, K. Ahrong2, K. Young Keum2, K. Kyungbin4, C. Kyung Un2, 3, *
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1
Department of Obstetrics and Gynecology, School of Medicine, Pusan National University, Yangsan-si, Gyeongsangnam-do, Pusan National University Hospital, Busan, Republic of Korea
2
Department of Pathology, Pusan National University Hospital, Busan, Republic of Korea
3
Department of Pathology, School of Medicine, Pusan National University, Yangsan-si, Gyeongsangnam-do, Republic of Korea
4
Deparment of Pathology, Ulsan University Hospital, Ulsan, Republic of Korea
†Contributed equally.
Eur. J. Gynaecol. Oncol. 2018, 39(5), 773–778;
https://doi.org/10.12892/ejgo4281.2018
Published: 10 October 2018
Abstract
Tumor hypoxia is associated with malignant progression and treatment resistance. Hypoxia-related factors (HRFs), such as hypoxiainducible factor 1α (HIF-1α), carbonic anhydrase IX (CA IX), and glucose transporter-1 (GLUT-1) permit tumor cell adaptation to hypoxia. The authors attempted to elucidate the correlation of these markers with variable clinicopathological factors and overall prognosis. Immunohistochemistry for HIF-1α, CA IX, and GLUT-1 was performed on formalin-fixed, paraffin-embedded tissues from 140 cases of endometrial carcinomas. Expression of HIF-1α, CA IX, and GLUT-1 was shown in 33.6% (47 cases), 47.9% (67 cases), and in 67.1% (94 cases) HIF-1α and GLUT-1 expression was significantly associated with myometrial invasion. CA IX expression was associated with histologic grade and tumor stage, as well as myometrial invasion. HIF-1α expression was associated with a shorter OS. The present study suggests that expression of these hypoxia-related factors tends to be associated with poor prognosis, and HIF-1α expression is an independent unfavorable prognostic factor in endometrial carcinomas.
Keywords
Endometrial carcinoma
Hypoxia
HIF-1α
CA IX
GLUT-1