IMR Press / EJGO / Volume 39 / Issue 5 / DOI: 10.12892/ejgo4281.2018

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Original Research
Differential regulation and prognostic significance of endogenous hypoxic markers in endometrial carcinomas
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1 Department of Obstetrics and Gynecology, School of Medicine, Pusan National University, Yangsan-si, Gyeongsangnam-do, Pusan National University Hospital, Busan, Republic of Korea
2 Department of Pathology, Pusan National University Hospital, Busan, Republic of Korea
3 Department of Pathology, School of Medicine, Pusan National University, Yangsan-si, Gyeongsangnam-do, Republic of Korea
4 Deparment of Pathology, Ulsan University Hospital, Ulsan, Republic of Korea
†Contributed equally.
Eur. J. Gynaecol. Oncol. 2018, 39(5), 773–778;
Published: 10 October 2018

Tumor hypoxia is associated with malignant progression and treatment resistance. Hypoxia-related factors (HRFs), such as hypoxiainducible factor 1α (HIF-1α), carbonic anhydrase IX (CA IX), and glucose transporter-1 (GLUT-1) permit tumor cell adaptation to hypoxia. The authors attempted to elucidate the correlation of these markers with variable clinicopathological factors and overall prognosis. Immunohistochemistry for HIF-1α, CA IX, and GLUT-1 was performed on formalin-fixed, paraffin-embedded tissues from 140 cases of endometrial carcinomas. Expression of HIF-1α, CA IX, and GLUT-1 was shown in 33.6% (47 cases), 47.9% (67 cases), and in 67.1% (94 cases) HIF-1α and GLUT-1 expression was significantly associated with myometrial invasion. CA IX expression was associated with histologic grade and tumor stage, as well as myometrial invasion. HIF-1α expression was associated with a shorter OS. The present study suggests that expression of these hypoxia-related factors tends to be associated with poor prognosis, and HIF-1α expression is an independent unfavorable prognostic factor in endometrial carcinomas.
Endometrial carcinoma
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