IMR Press / EJGO / Volume 39 / Issue 5 / DOI: 10.12892/ejgo4217.2018

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Original Research
Evaluation of three-dimensional ultrasound measurement techniques used to assesses myometrial invasion in endometrial cancer
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1 Department of Gynecology and Obstetrics, Aarhus University Hospital, Aarhus, Denmark
2 Department of Clinical Physiology and Nuclear Medicine, Herlev and Gentofte Hospital, Herlev, Denmark
3 Department of Gynecology and Obstetrics, Rigshospitalet, Copenhagen, Denmark
4 Department of Histopathology, Aarhus University Hospital, Aarhus, Denmark
Eur. J. Gynaecol. Oncol. 2018, 39(5), 710–717;
Published: 10 October 2018

Purpose: To assess interobserver variation and efficiency of various measurements on 3-dimensional transvaginal ultrasound (3DTVS) and saline infusion sonography (3D-SIS) for preoperative measurement of deep myometrial invasion (DMI) in endometrial cancer. Materials and Methods: One hundred ten women with atypical endometrial hyperplasia or endometrial adenocarcinoma had preoperative 3D-TVS and 3D-SIS. Endometrial thickness (ET), ET in percent of uterine diameter (PAP) and various volumes were measured. AUC, sensitivity, and specificity of most optimal cut-points, and kappa statistics for observer variation were calculated. Results: PAP identified two-thirds of women with DMI. ET and 3D volume measurements had substantial observer agreement compared to moderate agreement of subjective evaluation of DMI. AUC for measurements ranged 0.63–0.73 for identification of DMI. Subjective evaluation of DMI had highest AUC only marginally improved by adding PAP. Conclusion: Preoperative staging of endometrial cancer is not improved by adding 3D volume measurements to subjective evaluation, but PAP could be used to select women with a high risk of DMI for further MRI.
Endometrial neoplasms
Tumor burden
Preoperative procedures
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