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European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.
Relationship of ovarian cancer tumour markers’ concentration between local fluid and serum: comparison of malignant to benign condition
B. Kobal1, 2, K. Galic Jerman1, 2, J. Karo3, I. Verdenik1, 2, K. Cerne1, 2, *
1 Department of Gynaecology, Division of Gynaecology and Obstetrics, University Medical Centre Ljubljana, Ljubljana, Slovenia
2 Department of Gynaecology and Obstetrics, Faculty of Medicine, University Ljubljana, Ljubljana, Slovenia
3 Institute of Pharmacology and Experimental Toxicology, Faculty of Medicine, University Ljubljana, Ljubljana, Slovenia
Eur. J. Gynaecol. Oncol. 2018, 39(5), 743–750;
Published: 10 October 2018
Objective: The aim of the study was to evaluate the relationship of ovarian tumour markers osteopontin (sOPN) and splice variant 6 of sCD44 (sCD44-v6) between serum and local environment, represented by ascites or peritoneal fluid (PF) / peritoneal washing (PW), in patients with malignant and non-malignant conditions, respectively. Materials and Methods: The study included 33 women with advanced ovarian malignancy and 33 women with benign gynaecological conditions. Tumour markers concentrations were determined by flow cytometry. Results: Mean concentrations in ascites for both tumour markers were significantly higher than in PF or PW. Serum sOPN concentrations did not correlate with local fluid levels in either group and showed a tendency for retention in local fluid which was potentiated in malignant condition. Serum sCD44-v6 concentrations positively correlated with concentrations in ascites, PF, and PW. However, the magnitude of slope of the regression line was lower in malignant situation. Conclusion: Although concentrations of both potential biomarkers significantly increase in ascites produced by metastatic ovarian cancer, serum values are not a simple reflection of local environment changes.