IMR Press / EJGO / Volume 39 / Issue 4 / DOI: 10.12892/ejgo4379.2018

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Original Research
Clinical observation of short-term efficacies of different hypofractionated radiation therapies after modified radical mastectomy for breast cancer
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1 Department of Radiation Oncology, the General Hospital of the People’s Liberation Army, Beijing, China
Eur. J. Gynaecol. Oncol. 2018, 39(4), 524–532;
Published: 10 August 2018

The aims of this study were to analyze the acute and advanced responses of different hypofractionated radiation therapies (HFRT) after modified radical mastectomy for breast cancer (MRM-BC). A total of 162 patients were included into this prospective clinical Stage I-II study from October 2010 to May 2015, including 77 cases (group 42.5 Gy) and 85 cases (group 36.5 Gy). The acute and advanced side effects were analyzed according to static intensity modulation plan and Radiation Therapy Oncology Group (RTOG) classification criteria. There was no significant difference in the white blood cell reactions, acute skin reactions, and acute pharyngeal - esophageal reactions between group 42.5 Gy and 36.5 Gy, and no late complication was observed during follow-up. The median follow-up time of group 42.5Gy was 36 months and that of group 36.5 Gy was 12 months. There was no statistical significance in the local recurrencefree survival rate, disease-free survival rate, and distant metastasis rate between the two groups. There was no local recurrence or death in both groups (with the radiation field), and the local recurrence-free survival and overall survival rates of the two groups were both 100%. The incidence of acute adverse reactions and short-term efficacies of the two post-MRM-BC HFRT (42.5 Gy/16 F and 36.5 Gy/10 F) were similar, but the advanced adverse reactions and efficacies still need further observation.
Breast cancer
Modified radical mastectomy
Hypofractionated radiation therapy
Survival analysis
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