IMR Press / EJGO / Volume 39 / Issue 2 / DOI: 10.12892/ejgo3959.2018

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Original Research
Margin status of conization specimens obtained by see-and-treat strategy and three-step strategy
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1 Department of Obstetrics and Gynecology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
Eur. J. Gynaecol. Oncol. 2018, 39(2), 221–224; https://doi.org/10.12892/ejgo3959.2018
Published: 10 April 2018
Abstract

Purpose: To evaluate the margin status of conization specimens according to treatment strategy. Materials and Methods: A retrospective review was performed for patients who underwent conization at a single institution from January 2003 to August 2012. Cases were divided into two groups depending on whether the patient had undergone a punch biopsy before conization or not (the 'see-andtreat' group or the 'three-step' group). The final histologic results of the two groups were compared. Results: Of the 862 patients, 694 women were in the 'see-and-treat' group and 168 women were in the 'three-step' group. There was no significant statistical difference in the rate of cone margin involvement between the two groups. However, the cone margin involvement rate of patients with CIN 3 was higher in the 'see-and-treat' group (26.5% in the 'see-and-treat' group vs. 11.7% in the 'three-step' group; p = 0.012). When patients with HSIL cytology were subanalyzed, 'see-and-treat' group with CIN 3 had a trend toward high cone margin involvement rate than three-step group without statistical significance (24.4% in the 'see-and-treat' group vs. 9.0% in the 'three-step' group; p = 0.053). Conclusion: Without inspection of cervical precancerous lesion, the patients with high-grade squamous intraepithelial lesion (HSIL) treated by 'see-and-treat' strategy are more likely to show positive cone margin involvement.
Keywords
Cervical intraepithelial neoplasia
Conization
HSIL
‘See-and-treat’ strategy
Positive margin
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