IMR Press / EJGO / Volume 38 / Issue 4 / DOI: 10.12892/ejgo3616.2017

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Distinguished Expert Series
Uterine carcinosarcoma: the TAG systematic review
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1 Department of Obstetrics and Gynecology, Kuo General Hospital, Tainan, Taiwan
2 Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei, Taiwan
3 Departent of Nursing, Taipei Veterans General Hospital, Taipei, Taiwan
4 Department of Obstetrics and Gynecology, National Yang-Ming University School of Medicine, Taipei, Taiwan
5 Department of Medical Research, China Medical University Hospital, Taichung, Taiwan
6 Department of Family Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
7 Emergency Department, Taipei Veterans General Hospital, Taipei, Taiwan
8 Foundation of Female Cancer, Taipei, Taiwan
9 Taipei, Taiwan
Eur. J. Gynaecol. Oncol. 2017, 38(4), 489–499;
Published: 10 August 2017

Uterine carcinosarcoma (UCS: uterine malignant mixed Mullerian tumor, uterine MMMT, uterine MMT) is an uncommon but aggressive malignancy. Given that UCS is metaplastic carcinoma, the stage system is according to the 2009 FIGO (Federation of International Gynecology and Obstetrics) staging system for endometrial cancer. In addition, UCS is included into the classification of mixed epithelial and mesenchymal tumors of the uterus, based on the current 2014 World Health Organization (WHO) classification. The diagnosis of UCS is made in the presence of high-grade malignant epithelial and mesenchymal components typically showing a sharp demarcation. The principal treatment in early and locally advanced UCS is a complete and comprehensive staging surgery, including total hysterectomy, bilateral salpingo-oophorectomy, and systematic lymphadenectomy. For advanced-stage UCS, en-bloc debulking surgery is also beneficial for the patients. Multi-agent chemotherapy with and without radiotherapy is often prescribed for patients with UCS, because it might be associated with a better progression-free survival and overall survival. This review summarizes and analyzed the updated information of this highly aggressive disease.
Endometrial cancer
Uterine carcinosarcoma
Uterine malignant mixed Mullerian tumor
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