IMR Press / EJGO / Volume 38 / Issue 4 / DOI: 10.12892/ejgo3307.2017

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Open Access Original Research
Association between SNPs in Wnt signaling pathway genes and ovarian cancer risk in Northern Chinese population
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1 Department of Pathology, TianJin Cancer Hospital, TianJin Medical University, TianJin, China
2 Department of Pathology, Mudanjiang Medical University, Mudanjiang, China
3 Department of Gynecology, The Affiliated Cancer Hospital, Harbin Medical University, Harbin, China
4 Department of physiopathology, Mudanjiang Medical University, Mudanjiang, China
Eur. J. Gynaecol. Oncol. 2017, 38(4), 529–532; https://doi.org/10.12892/ejgo3307.2017
Published: 10 August 2017
Abstract

Objective: Wnt signaling pathway is important for tumorigenesis, due to its regulation of many critical biological processes, while the association between SNPs in Wnt pathway genes and ovarian cancer risk has not been established in Chinese, the authors performed a large case control study to analyze this association. Materials and Methods: A case control study was designed including 732 ovarian cancer cases and 765 controls. A total of six SNPs in five core genes in Wnt pathway were genotyped in all the samples. Logistic regression analysis was performed to evaluate the association between SNPs and ovarian cancer risk, odds ratios (ORs), and 95% confidence intervals (CIs) were estimated. Results: In the univariate analysis, among the six SNPs, the authors found two SNPs significantly associated with ovarian cancer risk. One is SNP rs4135385 in β-catenin gene, compared with AA genotype, GG genotype was associated with a significant lower risk of ovarian cancer, OR=0.62; 95% CI (0.45, 0.87). The other is SNP rs6485350 in DKK3 gene, compared with GG genotype, AA genotype was associated with a significant lower risk of ovarian cancer, OR=0.73; 95% CI (0.55, 0.98). In the multivariate analysis adjusting for common demographic variable, the authors found SNP rs4135385 in β-catenin gene significantly associated with ovarian cancer risk, Compared with AA genotype, GG genotype was associated with a significant lower risk of ovarian cancer, OR=0.57; 95% CI (0.40, 0.79), p = 0.006. After Bonferroni’s correction for six SNPs, this SNP rs4135385 was still significantly associated with ovarian cancer risk. Conclusion: In this case control study, the authors found significant association between SNP in β-catenin gene and ovarian cancer risk in Northern Chinese and further studies are warranted to validate their finding and investigate the mechanism for the association.
Keywords
Ovarian cancer
Case control study
Wnt pathway
beta-catenin
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