IMR Press / EJGO / Volume 38 / Issue 3 / DOI: 10.12892/ejgo3579.2017

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Open Access Original Research
Mucin expression profile of benign and malignant cervical tissues and correlation with clinical-pathologic parameters
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1 Department of Obstetrics and Gynecology, Clinical Medical College of Yangzhou University, Yangzhou, China
Eur. J. Gynaecol. Oncol. 2017, 38(3), 350–355; https://doi.org/10.12892/ejgo3579.2017
Published: 10 June 2017
Abstract

Purpose: To detect the expression of mucins in diverse benign and malignant cervical tissues of cervical disease. Materials and Methods: 158 cases of cervical tissues were collected. Sections were stained with monoclonal antibodies against MUC1, MUC2, MUC4, MUC5AC, and MUC20 by immunohistochemistry. Results: Normal cervical epithelium showed high expression of MUC1, MUC4, and MUC5AC, partial expression of MUC20, and no MUC2. With the development from chronic cervicitis, cervical intraepithelial neoplasia (CIN) to cervical squamous cell carcinoma (SCC), the expression of MUC1, MUC4, and MUC20 was statistically significant. The expression of MUC1 was related with the depth of invasion and clinical stage of SCC. The positive rates of MUC4 and MUC20 were associated with the degree of differentiation and clinical stage of SCC. There was a correlation between the expression of MUC4, MUC1, and MUC20 in cervical squamous lesions. Conclusion: Mucins may be involved in the development of cervical cancer.
Keywords
Mucin
Cervical intraepithelial neoplasia (CIN)
Squamous cell carcinoma (SCC)
Adenocarcinoma
Clinical-pathologic parameters
Immunohistochemistry
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