IMR Press / EJGO / Volume 38 / Issue 2 / DOI: 10.12892/ejgo3408.2017

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Original Research
Direct uterine sampling using the SAP-1 sampler device to detect endometrial lesions during histopathological examination
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1 Department of Gynecology and Obstetrics, Peking University People's Hospital, Beijing, China
1 Department of Pathology, Peking University, Beijing People's Hospital, Beijing, China
Eur. J. Gynaecol. Oncol. 2017, 38(2), 221–226;
Published: 10 April 2017

Aims: To evaluate the sampling adequacy and diagnostic accuracy of the endometrial SAP-1 sampling device in detecting endometrial lesions based on histopathological examination. Materials and Methods: In total, 182 patients who required an endometrial biopsy were enrolled in this study. All of the patients underwent endometrial biopsies with the SAP-1 sampler prior to hysteroscopy (169/182) or dilatation and curettage (D&C) (13/182). Endometrial tissues were obtained at biopsy for histopathological examination. Results: Adequate endometrial specimens were obtained in 148 of 182 patients (81.32%). Menopause (p = 0.000), endometrial thickness (p = 0.004), and the types of endometrial diseases (p = 0.009) differed significantly between the two groups. Among the 169 patients who underwent hysteroscopy, sampling scratches were observed in the uterine cavity in 147 cases (86.98%). Compared to traditional methods, such as hysteroscopy and D&C, the sampling diagnostic sensitivity, specificity, and positive and negative predictive values were 82.35%, 100%, 100% , and 97.76% for endometrial carcinoma (n=17) and 37.5%, 100%, 100% and 97.76% for endometrial atypical hyperplasia (n=8), respectively. Those that were misdiagnosed occurred because the lesions were focal or localized in a small part of the uterine cavity. The sampling diagnostic sensitivity for polyps (n=32) was 12.5%. Two patients with submucosal leiomyoma went undiagnosed based on the sample specimens. Conclusion: Endometrial sampling using the SAP-1 sampler is a minimally invasive alternative technique for obtaining adequate endometrial specimens for histopathological examination. The SAP-1 sampler was useful in detecting endometrial carcinoma and atypical hyperplasia cases that were not highly suspected to be localized; however, this method was not useful in detecting endometrial polyps and submucosal leiomyomas.
Endometrial sampling
Endometrial carcinoma
Endometrial atypical hyperplasia
Endometrial lesions
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