IMR Press / EJGO / Volume 38 / Issue 1 / DOI: 10.12892/ejgo3348.2017

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Case Report
A case of melanocytic cervical adenosquamous carcinoma complicated with Cushing’s syndrome
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1 Department of Obstetrics, Central Hospital of Benxi City, Liaoning, China
2 Department of Gynecology, The First Affiliated Hospital of China Medical University, Shenyang, China
3 Department of Orthopedics, Central Hospital of Beixi City, Liaoning, China
Eur. J. Gynaecol. Oncol. 2017, 38(1), 126–128;
Published: 10 February 2017

Background: To date, cervical carcinoma complicated with Cushing's syndrome were all diagnosed as small cell carcinoma histologically, but not adenosquamous carcinoma. Here the authors present the diagnosis, management, and prognosis of a case of melanocytic cervical adenosquamous carcinoma complicated with Cushing's syndrome. Case: A 28-year-old woman was admitted with the chief complaint of post-coital bleeding for one month. Gynecological examination revealed a nodular yellowish-pigmented vegetation (6×5 cm) on the cervix. Laboratory findings proved the diagnosis of Cushing’s syndrome. Histopathological diagnosis showed the adenosquamous carcinoma with melanoma differentiation. Immunohistochemical stainings for melanoma A and anti-adrenocorticotropic hormone (ACTH) were positive in the majority of the tumor cells, which indicated that this melanocytic cervical carcinoma lesion was the source of ectopic ACTH production resulting in Cushing's syndrome. Conclusion: This is a unique case of a rare type of cervical carcinoma.
Melanocytic carcinoma
Cervical adenosquamous carcinoma
Cushing’s syndrome
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