IMR Press / EJGO / Volume 37 / Issue 6 / DOI: 10.12892/ejgo3238.2016

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Case Report
Endometrioid adenocarcinoma arising from adenomyosis: a case report
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1 University of Pécs, Medical School, Department of Obstetrics and Gynaecology, Pécs, Hungary
2 MTA-PTE Human Reproduction Research Group, Pécs, Hungary
3 University of Pécs, Medical School, Institute of Pathology , Pécs, Hungary
4 Universitätsklinikum Giessen und Marburg GmbH, Frauenklinik, Germany
Eur. J. Gynaecol. Oncol. 2016, 37(6), 858–860;
Published: 10 December 2016

Background: Endometriosis is most commonly found in the peritoneum of the lesser pelvis and in the genital tract (in the ovaries). Its malignant transformation is quite rare, which usually appears in patients who previously underwent surgical procedures aimed at treating endometriosis. Years of hormone substitution (unopposed estrogen therapy) is also considered to have a role. According to the present authors' current knowledge, these are mostly well-differentiated tumors with low malignancy, which are primarily treated surgically. Case: In the present case the authors present a 73-year-old female patient who underwent a laparotomy due to abdominal pain and a mass in the lesser pelvis. The authors performed hysterectomy along with bilateral adnexectomy and omental resection. The histological examination of the specimens verified an endometrial adenocarcinoma formed on the ground of adenomyosis and the endometrial adenocarcinoma of the left ovary. Conclusion: The malignant transformation of endometriosis is rare, and the mechanisms how it develops on the grounds of adenomyosis is currently unclear.
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