IMR Press / EJGO / Volume 37 / Issue 3 / DOI: 10.12892/ejgo3024.2016

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Original Research
Pterostilbene induces apoptosis through caspase activation in ovarian cancer cells
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1 Department of Gynaecology and Obstetrics, Xiangyang Hospital Affiliated with Hubei University of Medicine, Xiangyang, China
2 Department of Gynaecology and Obstetrics, People's Hospital, Changyyi, China
Eur. J. Gynaecol. Oncol. 2016, 37(3), 342–347;
Published: 10 June 2016

Aim: Pterostilbene, an analog of resveratrol increasing bioavailability has shown to offer antioxidant and anticancer properties in vitro and in vivo. Dietary compounds with anti-oxidant properties have been shown to gain importance due to therapeutic applications. In addition, compounds with higher bioavailability levels show great interest in present scenario. Thus, the present study aimed at investigating the cytotoxic role of pterostilbene and its mechanism of cell death in ovarian cancer cells line. Materials and Methods: The effect of pterostilbene was determined on SKOV-3 cells, by cytotoxicity assays, oxidative stress levels, [Ca2+]i levels, mitochondrial depolarization, cell cycle analysis and caspase 3, 8, and 9 activities. Results: The study revealed that pterostilbene offered cytotoxic effect at a concentration of IC50-55 uM. Further, pterostilbene induced reactive oxygen species (ROS) mediated intrinsic pathway of apoptosis through enhancing oxidative stress, [Ca2+]i levels, mitochondrial depolarization, Sub G1 accumulation, and activation of caspase 3 and 9. Conclusion: The study demonstrates for the first time the cytotoxic potential of pterostilbene against ovarian cancer cells.
Oxidative stress
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