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Bone metastasis in endometrial cancer: evaluation of treatment approaches by factors affecting prognosis
E. Doğer Doğer1,*, Y. Çakıroğlu Çakıroğlu1, Ö. Özdamar Özdamar2, Y. Ceylan1, E. Köle Köle1, İ. Yücesoy Yücesoy1, E. Çalıskan Çalıskan1
1 Department of Obstetrics and Gynecology, Kocaeli University Faculty of Medicine, Kocaeli, Turkey
2 Department of Obstetrics and Gynecology, Gölcük Military Hospital, Kocaeli, Turkey
Eur. J. Gynaecol. Oncol. 2016, 37(3), 407–416; https://doi.org/10.12892/ejgo2862.2016
Published: 10 June 2016
Objective: The purposes of this study were to present an endometrial cancer case with a first sign of bone metastasis, and to reveal factors affecting survival and the appropriate treatment methods for bone metastases. Materials and Methods: A total of 101 case reports that presented with bone metastasis of endometrial cancer were reviewed in this study. Results: Survival time in the patients without surgical treatment for bone metastasis was found to be 12 months (95% CI = 5.89 - 18.10) and 42 months in patients who underwent surgical treatment in addition to one or more of chemo-radio-hormonotherapies (95% CI = 16.58 - 67.41) (p=0.006). Histological type of cancer, extra-osseous metastasis, and lack of surgery were the factors significantly affecting survival (p = 0.012, p = 0.002, and p = 0.038, respectively). Conclusion: Histological type and the presence of extra-osseous involvement are important prognostic markers in endometrial cancer patients with bone metastasis. It may be appropriate to implement combination therapies including surgery in the treatment of bone metastases.