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European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.
Serum lipid profile in gynecologic tumors: a retrospective clinical study of 1,550 patients
1 Department of Gynecology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China
2 Department of Cardiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China
3 Department of Cell Biology and Anatomy, University of South Carolina School of Medicine, Columbia, SC, USA
4 Department of Gynecology, Nanjing Maternity and Child Health Hospital, Affiliated Hospital of Nanjing Medical University, Nanjing, China
Eur. J. Gynaecol. Oncol. 2016, 37(3), 348–352; https://doi.org/10.12892/ejgo2854.2016
Published: 10 June 2016
Background: The study was performed to characterize and compare the serum lipid profile in gynecologic cancers and benign diseases. Materials and Methods: A total of 1,550 age-matched females were included in this study: 760 patients with gynecologic cancers and 790 patients with benign diseases. Serum levels of triglycerides (TG), high density lipoprotein cholesterol (HDL-c), low density lipoprotein cholesterol (LDL-c), total cholesterol (TC), and lipoprotein (a) were measured. Results: Compared to gynecologic benign disease group, gynecologic cancer group was associated with higher level of TG (p = 0.0002), as well as lower level of HDL-c (p < 0.0001), LDL-c (p = 0.004) and TC (p = 0.003). Compared to benign ovarian tumor group, ovarian cancer group had significantly lower levels of HDL-c (p < 0.0001), LDL-c (p = 0.0009), and TC (p < 0.0001), as well as a trend of higher level of lipoprotein (a) (p = 0.10). Compared to endometriosis group, endometrial cancer group showed higher levels of TG (p < 0.0001) and lower levels of HDL-c (p = 0.002). There was no significant difference in any lipid parameters between cervical cancer group and uterine leiomyomas group. Conclusion: In conclusion, compared with benign diseases, gynecologic cancers are associated with a disordered lipid profile characterized by higher TG and lipoprotein (a) levels, and lower HDL-c, LDL-c, and TC levels. The association is most conspicuous in ovarian cancers. Endometrial cancer is accompanied by alterations only in TG and HDL-c levels, while cervical cancer does not appear to be associated with disordered lipid profile.