IMR Press / EJGO / Volume 37 / Issue 2 / DOI: 10.12892/ejgo2837.2016

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Case Report
Twin delivery after IVF-ET with variable dose letrozole-FSH protocol of lower estradiol in a patient previously treated for breast cancer: a case report
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1 Reproductive Medical Center, Renmin Hospital, Shiyan, Hubei, China
2 Department of Thoracic and Cardiomacrovascular Surgery, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, China
Eur. J. Gynaecol. Oncol. 2016, 37(2), 278–281;
Published: 10 April 2016

Objective: To present a case of twin pregnancy obtained by in vitro fertilization and embryo transfer (IVF-ET) with variable dose letrozole- FSH protocol of lower peak estradiol level, after treatment of carcinoma of the breast. Materials and Methods: A 34-year-old patient diagnosed with mucinous breast carcinoma undergoing assisted fertilization treatment after breast cancer operation and treatment including controlled ovarian stimulation (COS), oocyte retrieval, IVF, and embryo culture and transfer. Results: Four oocytes were obtained in three COS procedures in the three IVF cycle. All oocytes were fertilized. In the third cycle, two fresh embryos were transferred, and two healthy girls were born at 37 gestational weeks. Conclusion: Variable dose letrozole-FSH protocol can maintain lower peak estradiol levels and reduce estrogen exposure after breast cancer operation and chemotherapy.
Breast cancer
Variable dose letrozole-FSH protocol
Twin pregnancy
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