Purpose of investigation: To report and explore the effectiveness of the endoscopic surgery combining cisplatin, etoposide, and bleomycin (PEB) chemotherapy in treating vaginal yolk-sac tumor. Case Report: The clinical case of vaginal yolk-sac tumor in a young girl was analyzed. Hysteroscopy equipment was used to inspect and remove the majority of the tumor tissue, followed by six cycles of PEB chemotherapy. Hysteroscopy equipment was used again to exam the vagina and remove of the tumor pedicle for biopsy, which revealed no tumor cells after two cycles of chemotherapy. The patient remained disease free on follow up for a year. Conclusion: The use hysteroscopy equipment to exam vagina can diagnose early vaginal yolk-sac tumor and cytoreductive surgery which can preserve fertility can then be performed. Cytoreductive surgery may also be able to reduce the cycles of the chemotherapy to reduce the side effects and the risks of chemotherapy.