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European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.
GTPases Rho distribution in intraepithelial and invasive neoplasias of the uterine cervix
M. Gomes Salles Tibúrcio Tibúrcio1, N. M. Pinheiro1, S. de Sales Costa Moreira Carboni1, L. P. Rocha1, S. J. Adad2, P. J. Maluf3, E. F. Cândido Murta3, V. O. Crema1,*
1 Structural Biology Department, Biological and Natural Sciences Institute, Federal University of Triângulo Mineiro, Uberaba, Minas Gerais
2 Special Pathology Department, Health Sciences Institute, Federal University of Triângulo Mineiro, Uberaba, Minas Gerais
3 Oncology Research Institute (IPON)/Discipline of Gynecology and Obstetrics, Health Sciences Institute, Federal University of Triângulo Mineiro, Uberaba, Minas Gerais (Brazil)
Eur. J. Gynaecol. Oncol. 2014, 35(3), 284–288; https://doi.org/10.12892/ejgo24142014
Published: 10 June 2014
Purpose of investigation: To evaluate the distribution of GTPases RhoA, RhoB, and Cdc42 in cervical intraepithelial neoplasias (CIN) and invasive neoplasias of the uterine cervix. Materials and Methods: samples of neoplastic lesions of the uterine cervix of 44 patients were classified in: CIN I (n = 10), CIN II (n=10), CIN III (n = 09), and invasive carcinoma (n = 15). Antibodies anti-RhoA, anti-RhoB, and anti-Cdc42 were used and staining was classified as: negative, mild, moderate, and intense positive. Results: When compared with dysplastic cells, superficial cells showed: higher expression of RhoB in CIN I (p = 0.0018), and lower expression of Cdc42 in CIN I (p = 0.0225). The authors observed higher expression of RhoA (p = 0.0002) and RhoB (p = 0.0046) in CIN dysplastic cells when compared with invasive carcinoma cells. Conclusions: GTPases Rho may be involved with the regulation of biological processes, important to the progression of cervical neoplasias. Probably, RhoA is important for maintenance of cell differentiation and RhoB protects cells from malignant cervical neoplasia.