IMR Press / EJGO / Volume 35 / Issue 3 / DOI: 10.12892/ejgo23882014

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Original Research
Cervical intraepithelial neoplasia based on array comparative genomic hybridization
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1 Department of Obstetrics and Gynaecology, College of Medicine, Soonchunhyang University, Cheonan
2 Department of Obstetrics and Gynaecology, College of Medicine, Soonchunhyang University, Bucheon (Republic of Korea)
Eur. J. Gynaecol. Oncol. 2014, 35(3), 270–273;
Published: 10 June 2014

Uterine cervical cancer is one of the most frequently observed malignant gynaecologic tumors. Carcinoma in situ or invasive cervical carcinoma develops from a low-grade intraepithelial lesion of the cervix over time. Human papillomavirus (HPV) is known to be a major contributing factor. With improvements in molecular genetic technologies, the authors attempted to identify the genomic changes associated with cervical precancerous lesions. In this study, changes in gene copy numbers were evaluated in five cases of severe uterine cervical dysplasia (HPV negative, two cases; HPV 16 and 18 positive only, three cases) by array comparative genomic hybridization(array CGH), and genes with copy number changes were compared between the two groups. Between the HPV positive and negative groups, only one gene was found to be upregulated more than 1.5 fold (3q23-q24), and no downregulated genes were identified. In conclusion, it is useful to evaluate genomic aberrations in cervical cancer using array CGH.
Comparative genomic hybridization
Uterine cervical neoplasms
Human papillomavirus>
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