IMR Press / EJGO / Volume 35 / Issue 2 / DOI: 10.12892/ejgo25012014

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Original Research
Management of breast lobular carcinoma in situ: radio-pathological correlation, clinical implications, and follow-up
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1 Gynecologic and Obstetric Clinic, University of Sassari, Sassari
2 Institute of Radiology, University of Sassari, Sassari
3 Institute of Pathologic Anatomy, University of Sassari, Sassari
4 Gynecologic and Obstetric Clinic, University of Padua, Padua (Italy)
Eur. J. Gynaecol. Oncol. 2014, 35(2), 157–162;
Published: 10 April 2014

Purpose of investigation: to show management of patients with breast lobular carcinoma in situ (LCIS). Materials and Methods: This study is the retrospective review of 65 patients, between 1996 and 2012, with isolated LCIS of the breast, evaluated through clinical examination, ultrasound, and mammography at the first examination and follow-up. Results: In 53 patients (81.54%), clinical examination was negative. In 14/65 (21.54%) cases, ultrasound was positive and led to biopsy. The clusters of tiny calcifications were the predominant mammographic pattern (45 cases, 69.23%). Forty-six patients (70.77%) underwent surgical biopsy after guided stereotactic placement of metallic marker (hook-wire), 12 (18.46%) by stereotactic vacuum biopsy (SVB), 5 (7.69%) by core needle biopsy (CNB) under ultrasound guidance, two (3.08%) patients CNB with clinically palpable nodules. Fourteen (21.54%) women underwent a quadrantectomy or total mastectomy after the first diagnosis; in this latter group follow-up was negative. Among the 51 patients (78.46%) who did not undergo quadrantectomy or total mastectomy, five relapses occurred, respectively, three LCIS and two infiltrating ductal carcinomas (IDC). Follow-up ranged from 12 to 144 months. Conclusion: LCIS is a risk factor for invasive carcinoma and should be managed with careful follow-up, but if there is a discrepancy between pathology and imaging, surgical excision is mandatory.
Lobular carcinoma in situ (LCIS)
Breast cancer
Lobular intraepithelial neoplasia (LIN)
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