IMR Press / EJGO / Volume 35 / Issue 1 / DOI: 10.12892/ejgo24492014

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Original Research
The correspondence between abnormal transformation zone Grade 1 and Grade 2 colposcopic parameters and histology. Clinical implications
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1 Department of Life, Health and Environmental Sciences, University of L’Aquila, L’Aquila
2 Department of Preventive Medicine, University of L’Aquila, L’Aquila
3 Department of Life, Avezzano Hospital, L’Aquila (Italy)
Eur. J. Gynaecol. Oncol. 2014, 35(1), 16–19;
Published: 10 February 2014

Objective: To analyse the correlation between the colposcopic parameters of Grade 1 and Grade 2 abnormal transformation zone (ANTZ G1 – ANTZ G2) and histological examination of the cone. Materials and Methods: A retrospective analysis of medical records of 600 women who underwent colposcopy and conisation (large loop excision of the transformation zone - LLETZ) between January 1, 2009 and July 31, 2012. The correlation between colposcopic and histological parameters was analysed using the Spearman nonparametric test. Results: In ANTZG1 there was no correlation (r= - 0.03; p = 0.55); in ANTZG2 however, a low degree of correlation (r = 0.21; p = 0.03) was found. Sensitivity, specificity, and positive and negative predictive values of an ANTZ G2 colposcopic picture were 33.45% (confidence interval [CI] 95% 28.0% to 39.2%), 95.48% (CI 95% 92.5% to 97.5%), 87.4% (CI 95% 79.7% to 92.9%), and 60.5% (CI 95% 56% to 64.9%), respectively. Conclusions: The decisive factor in the diagnosis of the cervical oncologic pathologies is the histological examination of the cone, and not the colposcopy which should be seen as a “guiding” investigation in predicting conisation and application of the most appropriate treatment.
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