IMR Press / EJGO / Volume 35 / Issue 1 / DOI: 10.12892/ejgo23982014

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Case Report
A 29-year-old woman with complex atypical hyperplasia and polycystic ovary syndrome: a challenging issue
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1 Department of Gynecological-Obstetric and Urological Sciences, University of Rome “Sapienza”, Sant’Andrea Hospital, Rome (Italy)
Eur. J. Gynaecol. Oncol. 2014, 35(1), 97–99;
Published: 10 February 2014

Background: The standard treatment for complex atypical hyperplasia is hysterectomy and bilateral salpingo-oophorectomy. Although radical surgery offers high survival prospects, it also eliminates any chance of further fertility, thus in young nulliparous women who wish to preserve their childbearing potential, a conservative progestin therapy is preferable. Case report: The authors report a case of complex atypical hyperplasia in a 29-year-old nulliparous woman with polycystic ovary syndrome treated with norethisterone acetate in order to preserve her childbearing potential. The specimens sampled during the follow-up demonstrated inactive endometrium with pseudodecidual changes and no ultrasonographic images exhibited abnormal endometrial thickness. Conclusion: According to literature and to the authors’ experience, they can affirm that progestin treatment is the most reasonable option for young nulliparous women affected by complex atypical hyperplasia who desire to maintain their fertility potential, showing its efficacy also in patients with an associated polycystic ovary syndrome.
Complex atypical hyperplasia
Uterus-sparing management
Norethisterone acetate
Young woman
Polycystic ovary syndrome.
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