IMR Press / EJGO / Volume 35 / Issue 1 / DOI: 10.12892/ejgo23802014

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Case Report
Mitotically active cellular fibroma of the ovary: a case report and a review of the literature
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1 Department of Gynaecology, Nanjing Medical University Affiliated Nanjing Hospital (Nanjing First Hospital), Nanjing
2 Department of Pathology, Nanjing Medical University Affiliated Nanjing Hospital (Nanjing First Hospital), Nanjing
3 Department of Obstetrics and Gynecology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, (P.R. China)
Eur. J. Gynaecol. Oncol. 2014, 35(1), 81–83;
Published: 10 February 2014

Mitotically active cellular fibroma (MACF) is characterized by increased cellularity, mitotic activity, and less frequently, nuclear atypia, which comprises 10% of ovarian fibromatous tumors. The authors report the case of a 76-year-old woman who presented at the present hospital with a two-month pelvic mass. B ultrasound disclosed a 75 × 52 × 41 mm mass in the right accessories. A hysterectomy and bilateral salpingo-oophorectomy was performed. Histologically, the tumor was composed of a densely cellular proliferation of fibrolastic-like cells with bland nuclear features and arranged in a fascicular pattern. There were more than four mitotic figures per ten high-power fields (HPFs). The histological diagnosis for the mass of the right ovary was MACF. MACF should be distinguished from ovarian fibrosarcoma. MACF is a recent histopathologic entity. Despite the high count of mitotic figures, the clinical course of the tumor is typically uneventful. Long-term clinical follow-up is recommended.
Mitotically active cellular fibroma
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