European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.
Cite this article
Pure primary osteosarcoma of the breast: a case report
S. D. Jakovljevic1, M. B. Spasic1,4, M. Z. Milosavljevic2, G. L. Azanjac1, Z. M. Protrka3,4, D. M. Radovanović Radovanović1,4, S. L. Mitrovic2,4,*
1 Surgery Clinic, Clinical Center Kragujevac, Kragujevac
2 Department of Pathology, Clinical Center Kragujevac, Kragujevac
3 Department of Gynecology and Obstetrics, Clinical Centre Kragujevac, Kragujevac
4 Faculty of Medical Sciences, University of Kragujevac, Kragujevac (Serbia)
Eur. J. Gynaecol. Oncol. 2013, 34(5), 476–479;
Published: 10 October 2013
Introduction: Mammary sarcomas are relatively uncommon and they represent less than one percent of all primary breast malignancies. Osteosarcoma of the breast, unassociated with other tumors, is distinctly rare, with published references generally limited to case reports and occasional cases in several series encompassing a heterogeneous group of mammary sarcomas and extraosseous osteosarcomas at various sites. The authors present a patient with pure osteosarcoma of the breast, osteoblastic type, with biologically aggressive pattern. Case Report: A 79-year-old lady became aware of a rapidly enlarging lump in the lateral part of the right breast. Clinical examination revealed a firm to hard, mobile, irregular, and painful breast lump measuring about six by four cm. On examination there was no axillary or supraclavicular lymphadenopathy. After initial diagnosis, excisional biopsy without dissection of the axillary lymph nodes was performed. Therefore, the histological and immunohistochemical findings established the diagnosis of pure primary osteosarcoma of the breast. Conclusion: Pure osteosarcoma of the breast is extremely rare and needs to be distinguished from a variety of benign and malignant breast lesions producing metaplastic bone. Less than a hundred cases of pure osteosarcoma of the breast were reported, but diagnostic confirmation with immunohistochemistry has been performed in relatively few of these cases.