IMR Press / EJGO / Volume 34 / Issue 3 / pii/1630906232499-197628245

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Original Research
Morular endometrial metaplasia: review of the literature and proposal of the management
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1 Department of Women’s and Children’s Health, Obstetrics and Gynecology Clinic, University of Padua, Padua (Italy)
Eur. J. Gynaecol. Oncol. 2013, 34(3), 243–247;
Published: 10 June 2013

Purpose of investigation: Morular endometrial metaplasia is a rare condition that can be often misdiagnosed and overtreated, because it can be mistaken for a malignant disease. The aim of this review was to update the current opinion on the significance of this pathology and its risk for potential malignancies. Materials and Methods: The authors report their experience of two cases of morular metaplasia involving very young women managed conservatively with hysteroscopic resection of the affected areas. Results: Hysteroscopic resection of these lesions can be an adequate and fertility-sparing treatment of morular metaplasia in women of childbearing age. Conclusions: Morular metaplasia has indeed a mutational origin but it is a benign andhormonally inert condition. The risk to develop cancer is closely associated with premalignant or malignant endometrioid glandular proliferations that are often associated with hysthological finding of morules rather than with morules themselves. Management of this condition requires trained pathologists and gynecologists and should be adapted to the age of the patient.
Endometrial metaplasia
Operative hysteroscopy
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