IMR Press / EJGO / Volume 34 / Issue 1 / pii/1630905352530-1567055187

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Open Access Original Research
Expression of E-cadherin in primary endometrial carcinomas: clinicopathological and immunohistochemical analysis of 30 cases
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1 Third Department of Obstetrics and Gynecology, “Elena Venizelou” General Maternity State Hospital, Athens
2 Department of Pathology, “Tzaneio” General State Hospital, Piraeus
3 Department of Obstetrics and Gynecology, “G. Chatzikosta” General State Hospital, Ioannina
4 Second Department of Obstetrics and Gynecology, University of Athens, Athens
5 Hellenic Centre for Diseases Control and Prevention (Greece)
Eur. J. Gynaecol. Oncol. 2013, 34(1), 31–35;
Published: 10 February 2013
Abstract

Introduction: Decreased expression of E-cadherin has been associated with poorly differentiated endometrial carcinomas and poorer outcomes. Aim: The purpose of this study was to examine the distribution of E-cadherin immunohistochemical expression in specimens from primary endometrial carcinomas and its relation to classical clinicopathological prognostic factors. Materials and Methods: Surgically-resected tissues of 30 patients with primary endometrial carcinomas were studied. Histological type and grade, depth of myometrial invasion, lymph-vascular space invasion, fallopian tube or ovarian invasion, and the presence of tumoral necrosis were evaluated. Immunohistochemical examination was performed on deparaffinized four-μm-thick sections. Results: The mean age of patients was 65 years (± 11.41). The 63.54% of carcinomas were moderately/poorly differentiated. No statistical correlation was found between the score or intensity of E-cadherin immunohistochemical staining (strong or moderate positive expression) and the clinicopathological factors tested. Conclusions: The association of E-cadherin immunoreactivity with the standard clinicopathological factors seemed to be contradictory. The classical clinicopathological factors remain the most important prognostic parameters.
Keywords
E-cadherin
Carcinoma
Endometrial
Endometrioid
Immunohistochemistry
Pathology
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