IMR Press / EJGO / Volume 32 / Issue 4 / pii/1630980372345-1381020228

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Original Research
Comparison of different ovarian cancer detection algorithms
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1 Riga Stradins University
2 Riga Eastern Clinical University Hospital
3 Riga Stradins University, A. Kirhenstein’s Institute of Microbiology and Virology, Riga (Latvia)
Eur. J. Gynaecol. Oncol. 2011, 32(4), 408–410;
Published: 10 August 2011

The objective of the study was to evaluate the accuracy of a combined-two step ovarian cancer screening tool consisting of the ovarian cancer symptom index combined with either a risk of ovarian malignancy algorithm (ROMA) or a risk of malignancy index. Material and Methods: The case-control study consisted of 31 patients with ovarian cancer, 30 patients with benign ovarian diseases and 27 age-matched healthy controls. Results: Sensitivity and specificity of the ovarian cancer symptom index among menopausal women were 84.6% and 52.9%, respectively. ROMA revealed the highest discriminative value when compared to others (AUC 98.4%). When the cutoff level of 28 was applied for menopausal women, ROMA revealed sensitivity and specificity of 95.8% and 93.1%, respectively. Conclusions: The ovarian cancer symptom index could be used as the first step in ovarian cancer screening with subsequent application of ROMA as a second step screening tool. A larger sample size in both control and patient groups should be evaluated to reach clear conclusions.
Ovarian cancer
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