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European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.
Immunological evaluation of vaginal secretion in patients with high-grade cervical intraepithelial neoplasia treated with intralesional interferon α-2b
M. C. Mardegan1, M. C. Ramos2, S. J. Adad3, M. A. Michelin4, D. Shimba5, E. F. C. Murta6,*
1 Gynecology and Obstetrics, UFTM
2 General Pathology, Oncology Research Institute (Instituto de Pesquisa em Oncologia-IPON), Federal University of the Triângulo Mineiro (UFTM)
3 Discipline of Special Pathology, UFTM
4 Oncology Research Institute (IPON)/Discipline of Immunology, UFTM, 5UFTM, 6Oncology Research Institute (IPON)/Discipline of Gynecology and Obstetrics, UFTM, Uberaba, Minas Gerais (Brazil)
Eur. J. Gynaecol. Oncol. 2011, 32(3), 297–302;
Published: 10 June 2011
Introduction: Conservative treatment with intralesional interferon (IFN) is a therapeutic option for cervical intraepithelial neoplasia (CIN) patients of childbearing age. Materials and Methods: The study group was made up of patients diagnosed with a highgrade lesion and treated with intralesional human recombinant IFNα-2b. Vaginal secretion was collected during IFNα-2b treatment for analysis of cytokines and viral load. Results: The initial histology diagnostic was 62.5% (n = 5) with CIN 2 and 37.5% (n = 3) with CIN 3. In terms of clinical evaluation and anatomopathology, 6.5% (n = 5) had a good clinical response, while 37.5% (n = 3) had therapeutic failure. All the patients with therapeutic failure were smokers. Interleukin 6 and tumor necrosis factor-α concentrations were raised at the sixth application for the patient group who failed to respond to therapy compared to the responsive group (p = 0.0357). Patients with a good response exhibited a reduction in human papillomavirus viral load (p = 0.03). Conclusions: Patients that had a good response had lower concentrations of inflammatory cytokines than did non-responders.
Human papillomavirus virus
Cervical intraepithelial neoplasia