Purpose: This study was designed to assess the safety and efficacy of a splenectomy and to analyze the prognostic factors of Mullerian carcinoma with spleen metastasis. Methods: We reviewed the medical records of 11 patients with Mullerian carcinoma who underwent a splenectomy between 1997 and 2007. The treatment outcome of these patients was examined and the possible prognostic factors were investigated by univariate analysis. Results: Four and seven patients underwent a splenectomy for primary and recurrent disease, respectively. A complete resection was achieved in eight patients. A blood transfusion was not required and only two mild postoperative complications were observed. The median and five-year survivals of all patients following treatment were 39 months and 39%, respectively. Older patients (_ 60 years old) and patients with a poor performance status (PS2) had a poorer prognosis by univariate analysis. Conclusions: A splenectomy can be performed safely and effectively during debulking surgery for appropriately selected patients with primary or recurrent Mullerian carcinoma.