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European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.
Original Research
Factors affecting recurrence and disease-free survival in granulosa cell tumors of the ovary
A. C. Iyibozkurt1,*, S. Topuz1, F. Gungor1, S. E. Akhan1, F. Demirci2, Y. Salihoglu1, S. Berkman1, E. Bengisu1
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1
Department of Obstetrics and Gynaecology, Istanbul Faculty of Medicine, Istanbul University, Istanbul (Turkey)
Eur. J. Gynaecol. Oncol. 2010, 31(6), 667–671;
Published: 10 December 2010
Abstract
Purpose of Investigation: To determine risk factors for prognosis and recurrence in ovarian adult-type granulosa cell tumor (GCT). Methods: A retrospective review of GCT cases treated at our university hospital between 1991-2006. Results: Of 39 patients with GCT, 82% had Stage I disease. The median follow-up period was 71 months. There were 12 cases of recurrence (30.8%) and seven of them had died of disease. The pelvis and liver were the most common sites of recurrence (8 and 3 patients, respectively). Interestingly lymph node recurrence was encountered in two patients. Estimated disease-free survival for five years was 82%. Stage and presence of residual tumor were calculated to be the only associated risk factors for recurrence and prognosis (p < 0.05). Conclusion: Recurrences in GCT might be associated with stage and presence of residual tumor during primary surgery. Although rarely present during diagnosis, lymph node metastasis might be more common in recurrent disease.
Keywords
Disease-free survival
Granulosa cell tumor
Ovary
Ovarian cancer
Prognosis
Recurrence
Stage