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European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.
Original Research
Overall survival in BRCA-associated ovarian cancer: case-control study of an Italian series
G. Artioli1,*, L. Borgato1, A. Cappetta1, J. Wabersich1, S. Mocellin1, M. Dalla Palma1, O. Nicoletto1
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1
Department of Medical Science, Oncology-Haematology Department, Mirano/Venice, Veneto Oncology Istitute I.O.V., Padova
1
Department of Obstetrics and Gynecology, Mirano/Venice Surgery Clinic II, University of Padova (Italy)
Eur. J. Gynaecol. Oncol. 2010, 31(6), 658–661;
Published: 10 December 2010
Abstract
About 10% of all ovarian cancers are due to BRCA 1 and/or BRCA 2 mutations. Some studies have shown that patients belonging to this group have a better survival compared to sporadic groups but data are still inconclusive. The aim of this study was to investigate overall survival in patients with ovarian cancer and germ-line mutations in the BRCA1/2 genes in comparison to highrisk patients, defined as patients with ovarian cancer and a strong family history of breast and ovarian cancer, but who tested negative for the BRCA mutation. We collected all the clinical features and did follow-up. The two groups showed similar characteristics concerning age at diagnosis, histological type and stage. Grade 3 was more frequent in the BRCA group. Survival data did not show any advantage for the BRCA mutated group.
Keywords
BRCA1
BRCA2
Ovarian cancer