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European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.
Expression of cytokines in cervical stroma in patients with high-grade cervical intraepithelial neoplasia after treatment with intralesional interferon α-2b
1 General Pathology, Oncology Research Institute (Instituto de Pesquisa em Oncologia-IPON), Federal University of the Triângulo Mineiro (UFTM)
2 Gynecology and Obstetrics, Uberaba, Minas Gerais
3 UFTM, Uberaba, Minas Gerais
4 Discipline of Special Pathology, UFTM, Uberaba, Minas Gerais
56 Oncology Research Institute (IPON)/Discipline of Gynecology and Obstetrics, UFTM, Uberaba, Minas Gerais (Brazil)
Eur. J. Gynaecol. Oncol. 2010, 31(5), 522–529;
Published: 10 October 2010
Conservative treatment with interferons (IFNs) has the advantage of preserving reproductive capacity in patients with grade 2 or 3 cervical intraepithelial neoplasia (CIN). The objective of this work was to study patients with high-grade CIN treated with intralesional IFN α-2b and to analyze the expression of Th1, Th2 and Th3 cytokines in cervical stroma. We observed that patients with a satisfactory response (60%) to treatment with IFN α-2b expressed more Th1 (IFN-γ TNF-α, IL-2) cytokines, with a significant reduction in the viral load of high-risk human papillomavirus (p = 0.0313). All patients with therapeutic failure were smokers and had higher expression of cytokines Th2 (IL-4) or Th3 (TGF-β2 and TGF-β3).
Cervical intraepithelial neoplasia