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High levels of xenoestrogens in patients with low-grade endometrial stromal sarcoma - report of two cases
1 Departments of Obstetrics and Gynecology, Medical University of Graz, Umweltbundesamt Vienna
2 Institute of Pathology, Medical University of Graz, Umweltbundesamt Vienna
3 Umweltbundesamt Vienna (Austria)
Eur. J. Gynaecol. Oncol. 2010, 31(1), 105–106;
Published: 10 February 2010
Background: Endometrial stromal sarcomas (ESS) are rare uterine tumors with unknown etiological risk factors, but estrogendependent growth promotion. Cases: We present two patients with advanced ESS, who had increased levels of p,p-DDE; hexachlorobenzene; PCB 28; PCB 52; PCB 101; PCB 138; PCB 153 and PCB 180 in abdominal adipose tissue. Other xenoestrogens were within expected limits for the non-exposed European population. Conclusion: Increased levels of xenoestrogens in patients with ESS may be involved in the pathogenesis of ESS. Chronic exposure to xenoestrogens may be a risk factor for tumor progression.
Endometrial stromal sarcoma